Hyperpigmentation is caused by the overproduction of pigment-producing melanin in some areas of the skin, and is characterized by dark spots or freckling. iS CLINICAL products for hyperpigmentation target the five major pathways of pigmentation to stop this overproduction; gently exfoliate to help remove hyperpigmented areas; and provide potent UV photoprotection to prevent the sun damage that often contributes to dark spots and freckling.